Protein Production and Analysis Platform Construction Consulting Services

Therapeutic recombinant protein drugs expressed in mammalian cells more closely resemble natural human proteins in structure and function. Rapid preparation of adequate and high-quality antigen and antibody proteins at different stages of drug development can facilitate flexible and comprehensive experimental design, thus accelerating drug development.

Protein purification/analysis platform technology is considered a valuable tool to improve the efficiency and quality of drug development. Platforms, combined with risk-based approaches, are the most systematic way to exploit a priori knowledge of a given new molecule. Furthermore, such a platform enables continuous improvement by adding data for each new molecule developed by this approach, thus increasing the robustness of the platform.

How Can We Help?

Creative BioMart Consulting provides comprehensive consulting support services throughout the construction of a protein purification/analysis platform. Based on our experience and taking into account the characteristics of your proteins, we will look for a set of promising approaches to building a purification platform with a focus on speed and purity. Depending on your requirements, we will further perform consulting support for downstream processing, providing complete process development for robust and scalable processes. By working closely with you, we will evaluate capacity, maximize yield and purity, determine impurity removal rates, and understand how subsequent steps are interrelated.

With our help, you can screen for optimal protein properties early in the process and integrate quality-derived design plans into their protein therapy development workflow. We provide consulting on building technology platforms that are not limited to the following

• Target protein selection and cloning: First, the target protein needs to be selected and then introduced into the expression vector and into the host cells by transformation and transfection.
• Protein expression and purification: The target protein is expressed in the host cell and then purified by techniques including affinity purification tags such as GST, His tags, HaloTag, and biotin, and pull-down for purification of protein complexes.
• Protein analysis: crystal diffraction techniques that determine the three-dimensional structure of proteins, thus helping drug designers understand the structure and function of proteins and their interactions with drugs. Mass spectrometry techniques allow the identification of protein sequences, chemical modifications, and other features, and determine the interaction of compounds with proteins.

In addition, we can provide you with consulting support in the following areas

• Highly versatile equipment for systematic process development
• Proven strategies for rapid process setup
• Analytical tools for protein products and process-related impurities, including HCP and host cell DNA

Advantages of The Platform We Designed

Our protein purification/analysis platform construction services can further improve the efficiency and effectiveness of your recombinant protein drug development.

• Production of high-purity protein samples to your specifications (GMP)
• Short turnaround time and high flexibility
• Projects tailored to your needs, from rapid setup to full development

Our Process

Creative BioMart Consulting is dedicated to provide state-of-the-art technology platform-building consulting services to clients seeking a protein purification/analytical platform. If you are looking to build an efficient protein purification/analysis platform, our professionals will provide you with a customized solution that will reliably meet your performance and quality expectations.